Dosing and Administration
Key Dosing and Administration Details About VPRIV
- The recommended starting dose of VPRIV for treatment naive patients 4 years and older is 60 Units/kilogram every other week given as a 60 minute intravenous infusion
- Patients 4 years and older who are currently being treated on a stable dosage of imiglucerase for type 1 Gaucher disease may be switched to VPRIV by starting treatment with VPRIV at the previous imiglucerase dosage 2 weeks after the last imiglucerase dose
- The recommended starting dose for treatment naive patients 4 years and older is 60 Units/kg
- Patients did not have to take any special medications before receiving infusions of VPRIV in clinical trials. Your healthcare professional might give you an antihistamine and/or corticosteroid before your infusion to help prevent an allergic reaction from happening. Pre-treatment medications for patients were not routinely required, however, in clinical studies.
- Dosage adjustments may be made based on achievement and maintenance of individual therapeutic goals
- These goals should be discussed between you and your doctor at the start of therapy
If You Experience a Hypersensitivity Reaction During an Infusion
If a serious allergic reaction (anaphlaxis) or acute reactions occur, your healthcare provider will immediately discontinue the infusion of VPRIV and initiate appropriate medical treatment. A hypersensitivity reaction should be treated based on the severity of the reaction. Your healthcare provider may manage a reaction by:
- Slowing the infusion rate
- Giving you medications such as antihistamines, fever-reducing agents, and/or corticosteroids
- Stopping the medication and then restarting with a longer infusion time
Be sure to speak with your doctor or healthcare professional if you have further questions about VPRIV infusions.